This research is one of the results of years of cooperation between the two teams. It is also the first time in the academic community to recognize that immune globulin gene abnormalities will induce systemic lupus erythematosus, which lays a solid foundation for further academic research and clinical targeted therapy.

Recently, Liu Wanli, a researcher at the School of Life Sciences, Tsinghua University, and Li Zhanguo, director of the Rheumatism and Immunity Center at Peking University People s Hospital, together with their teams discovered the existence of human immune globulin can increase the molecular variation of systemic lupus erythematosus susceptibility, and this kind of variation is involved in the regulation of immune B cells.

According to Sun Xiaolin, one of the authors and member of Peking University People s Hospital, the team of Li Zhanguo collected nearly 2,000 large samples of patients with systemic lupus erythematosus to make study. It was found that patients with immune globulin variations produced pathopoiesis cells and a wide variety of numerous autoantibodies. The incidence and severity of nephritis, arthritis, orrhomeningitis vasculitis and other inflammations are significantly increased.