And he lost his lower jaw, his lip, his chin and his upper jaw and teeth.

On land, life turned a corner. Jaws formed first teeth came later.

Would you feel the face and jaw, please?

We made a model of the jaw without bone in it.

But how we work on Jawbone is really unique.

Now I have no jaw left at all.

So this is a photograph of Henry, two weeks after he had a malignant cancer removed from the left side of his face his cheekbone, his upper jaw, his eye socket.

However, his chin skin doesn't look the same as it did before.

So Jawbone is a project that you're familiar with, and it has a humanistic technology.

One man was injured in the head, another in the shoulder and another one in the jaw.

And Hosain Rahman, the CEO of Aliph Jawbone, you know, really understands that you need a different structure.

I'd like you all in the audience now to push your lower jaw forward.

This is an image of Ann who's had her right jaw removed and the base of her skull removed.

It seems the human race is growing smaller jaws and having fewer teeth.

The doctors took a fibula bone from my leg and some tissue from my shoulder to fashion into a new jaw.

I doubt many of you in the audience can see the fossil that's in this picture, but if you look very carefully, there is a jaw, a lower jaw, of a 4.1 million year old upright walking ape as it was found at Lake Turkana on the west side.

And there's an orchid that might look to you as if it's got jaws, and in a way, it has it forces the insect to crawl out, getting covered in pollen that it takes somewhere else.

I can still see Hillary doing the shots of rye, dribbling down her chin, with the steel workers.

I was fortunate to find a dentist who applied this entire universe of technology you're about to see to establish that if he repositioned my jaw, the headaches pretty much resolved, but that then my teeth weren't in the right place.

But the teeth are ahead of the jaws and so everybody has more teeth than they know what to do with.

Chaz Ebert It was Chaz who stood by my side through three attempts to reconstruct my jaw and restore my ability to speak.

But the other thing that is humanistic about Jawbone is that we really decided to take out all the techie stuff, and all the nerdy stuff out of it, and try to make it as beautiful as we can.

So you see the nest maintenance workers come out with a bit of sand, put it down, turn around, and go back in.

I've chosen to show this profile view of Sue because what it shows is her lower jaw jutting forward and her lower lip jutting forward.

Turn to the person next to you, push your lower jaws forward. Turn to the person next to you and look at them they look miserable.

Because I had lost my jaw, I could no longer form a seal, and therefore my tongue and all of my other vocal equipment was rendered powerless.

And hold onto your seats, because if we zoom in on those faces, remark how they have the same broad forehead, the horizontal eyebrows, the long nose, the curved lips and the small, well developed chin.

If that sounds like a very, very strange thing to say and rather a bold statement How can the jaw affect the entire body? let me simply point out to you, if I ask you tomorrow to put one grain of sand between your teeth and go for a nice long walk, how far would you last before you had to remove that grain of sand?

The biological answer is simple a member of the species Homo sapiens that is characterized by such features as a relatively large brain set in a globular braincase, small brow ridges over the eyes, a small retracted face, a chin on the lower jaw, and a lightly built skeleton. Many of modern humans biological traits at least those that can be preserved as fossils were already present in Africa and Israel more than 100,000 years ago.

When film critic Roger Ebert lost his lower jaw to cancer, he lost the ability to eat and speak. But he did not lose his voice. In a moving talk from TED2011, Ebert and his wife, Chaz, with friends Dean Ornish and John Hunter, come together to tell his remarkable story.

The first report on which organizations are most effective at saving or transforming lives in Africa is now available on GiveWell s Web site, www.givewell.net . Population Services International, which promotes and sells items like condoms, to prevent HIV infection, and bed nets, to prevent malaria, came out on top, followed by Partners in Health, an organization that provides health care to poor rural populations.

Up, up, up.

Up, up, up.

I'm in love, I'm in love I'm in love, I'm in love

I'm in love, I'm in love, I'm in love

I'm in love, I'm in love I'm in love

Up, up, up. Let's go.

So hopefully everything has been positive, positive, positive, more positive.

Vegetably? Minerally? Animally? He's pretty much covered them there.

Good night. Good night.

Good evening, Irene. Good evening. Good evening.

Now come on, up this tree. Be safer up there.

Get on the horse immediately!

Captain, Captain.

Put it on, put it on.