Once you're insulin resistant, you're on your way to getting diabetes, which is what happens when your pancreas can't keep up with the resistance and make enough insulin.

Your pancreas makes insulin to bring it back down, which is good.

And insulin resistance, as its name suggests, is when your cells get increasingly resistant to the effect of insulin trying to do its job.

So now, when insulin says to a cell,

I had become insulin resistant.

Now you've all heard of at least insulin.

This is a typical insulin injection.

More importantly, I don't have insulin resistance.

What if obesity isn't the cause of insulin resistance at all?

I'll start with insulin, diabetes medication in the U.S.

This is a pen, it's called an insulin pen, preloaded.

Now failure to produce enough insulin is incompatible with life.

We know that 30 million obese Americans in the United States don't have insulin resistance.

But insulin accelerates the conversion of calories into fat.

And we do OK. Insulin's a pretty good therapy.

Why couldn't we just inject the pancreas with something to regenerate the pancreas early on in the disease, perhaps even before it was symptomatic?

Adherence rates. How many people are taking their insulin every day?

Have you been keeping up a normal diet since the last shot of insulin?

So if you can be obese and not have insulin resistance, and you can be lean and have it, this suggests that obesity may just be a proxy for what's going on.

The daf 2 hormone receptor is very similar to the receptor for the hormone insulin and IGF 1.

If you present with a diseased pancreas we'd like to take cells from that organ.

I became almost maniacally obsessed in trying to understand the real relationship between obesity and insulin resistance.

Now, most researchers believe obesity is the cause of insulin resistance.

There's one called TOR, which is another nutrient sensor, like the insulin pathway.

When we become insulin resistant, the homeostasis in that balance deviates from this state.

Insulin is a hormone that promotes the uptake of nutrients into your tissues after you eat a meal.

Trying to replace pancreas, trying to replace nerves that can help us with Parkinson's.

According to the source, the first autopsy gave the cause of death as pancreatitis .

A generous contribution of human insulin from a United States corporation channelled through a non governmental organization helped the Agency to meet its requirements for treatment of insulin dependent diabetes mellitus Agency wide in 1997 and 1998.

So what I'm suggesting is maybe we have the cause and effect wrong on obesity and insulin resistance.

So what if we're fighting the wrong war, fighting obesity rather than insulin resistance?

Logically, then, if you want to treat insulin resistance, you get people to lose weight, right?

Avandia, which debuted in 1999, is an insulin sensitizer , used for treating Type 2 diabetes.

In 1988, at the University of Minnesota, I participated in a small series of whole organ pancreas transplants.

On Medicaid if you're fairly poor you get Medicaid, or if you have health insurance insulin is pretty straightforward.

We have more trials planned for lung cancer, pancreatic cancer, ovarian cancer and breast cancer.

Meanwhile, our gatherer ancestors ate carbohydrates (polymers of glucose), which was also transported to the liver, via the glycolytic pathway, and broken down for energy. Any excess glucose stimulated the pancreas to release insulin, which transported glucose into peripheral fat tissue, and which also caused the liver to store glucose as glycogen (liver starch).

And the reason is that these hormones, like the insulin and the IGF hormones and the TOR pathway, they're essential.

I thought to myself, why not take the individual cells out of the pancreas the cells that secrete insulin to cure diabetes and transplant these cells? technically a much simpler procedure than having to grapple with the complexities of transplanting a whole organ.

Liver cells, nerve cells, pancreatic cells we still can't grow them even today.

And this inadequacy of cancer medicine really hit home when my father was diagnosed with pancreatic cancer.

This means that 40 or 45 percent of all school aged children could be insulin dependent within a decade. Within a decade.

Well, there are other cancer tumors in the abdomen quite lethal, very lethal actually pancreas, liver, kidney.

And also, there are other ways of activating FOXO that don't even involve insulin or IGF 1 that might even be safer.

If you ask yourself, what's a cell trying to protect itself from when it becomes insulin resistant, the answer probably isn't too much food.