No loo, no I do.

In England there's an expression you can't imagine the Queen on the loo.

The second one is, how do you go to the loo at minus 40?

Every one of us impacts the world around us everyday, and you scientists know that you can't actually even if you stay in bed all day, you're breathing oxygen and giving out CO2, and probably going to the loo, and things like that you're making a difference in the world.