Mice with multiple myeloma, an incurable malignancy of the bone marrow, respond dramatically to the treatment with this drug.

Poliomyelitis . 93.88

Rap to get for you...

And people are suffering from all kinds of pain like neuropathic pain, lower back pain and cancer pain from bone metastases, when the metastases get to your bones, sometimes they are very painful.

These cancers include acute lymphoblastic leukaemia acute myelogenous leukaemia chronic lymphocytic leukaemia hairy cell leukaemia non Hodgkin's lymphoma Hodgkin's disease melodysplastic syndrome multiple myeloma retinoblastoma Ewing sarcoma Wilms tumour neuroblastoma sarcoma rhabdomyosarcoma testis tumour and lung cancer.

I invented a device called the MarrowMiner, a much less invasive way for harvesting bone marrow.

His pails are full of milk. The marrow of his bones is moistened.

His pails are full of milk. The marrow of his bones is moistened.

His breasts are full of milk, and his bones are moistened with marrow.

His breasts are full of milk, and his bones are moistened with marrow.

And he sequenced, he took skin cells, healthy skin, and cancerous bone marrow, and he sequenced the whole genomes of both of them in a couple of weeks, no big deal.

So I am a pediatric cancer doctor and stem cell researcher at Stanford University where my clinical focus has been bone marrow transplantation.

So actually how do we harvest this bone marrow?

Some articles even went as far as to say that skeletal muscle tissue is resistant to cancer, and furthermore, not only to cancer, but of metastases going to skeletal muscle.

And we found, to our surprise, that we not only got bone marrow out, but we got 10 times the stem cell activity in the marrow from the Marrow Miner, compared to the normal device.

We use those in my field of bone marrow transplantation.

And hand it off to the nurse. She squirts it into a tin.

So, a few years ago, I'm doing my transplant fellowship at Stanford.

Fake it till you become it. You know? It's not Do it enough until you actually become it and internalize.

Daniel Kraft demos his Marrow Miner a new device that quickly harvests life saving bone marrow with minimal pain to the donor. He emphasizes that the adult stem cells found in bone marrow can be used to treat many terminal conditions, from Parkinson's to heart disease.

And so this informs, among other things, of course, a treatment for bone marrow transplant, which he undertakes.

Daniel Kraft invents a better way to harvest bone marrow

But starting in 2004, when antiangiogenic therapies first became available, well you can see that there has been a 70 to 100 percent improvement in survival for people with kidney cancer, multiple myeloma, colorectal cancer, and gastrointestinal stromal tumors.

We've just come out, we're commercializing, this year, generation 2.0 of the Marrow Miner.

We take our own bone marrow cells and treat a patient with a heart attack, we can see much improved heart function and actually better survival using our own bone marrow drive cells after a heart attack.

They picked as much broken bone as they could that had lodged in my spinal cord.

I'm in the operating room. We have Bob here, who is a volunteer donor.

More marrow transplantation centres have been established and more transplantations are being performed

(c) In the case of R. v. Cambridge Health Authority, the applicant was refused treatment of bone marrow transplant for her acute myeloid leukaemic condition because the National Health Service would not pay for it.

As one of the consequences of war, there are high rates registered of amputations, lesions of the spinal cord and bone marrow, traumatic injuries of brain, lesions of peripheral nerves and multiple traumas.

So I thought of a minimally invasive approach, and a new device that we call the Marrow Miner.

Marrow transplantation programme, with the aim of increasing the number of transplantation centres and the number of transplantations performed

Equally important, the risks and types of life threatening infections that come with myelosuppression were increasingly recognized, leading to the development and better use of more effective antibiotics. Starting in the 1990 s, cytokines, drugs that stimulate bone marrow to produce infection fighting white blood cells, began to be integrated into cancer treatments, further mitigating the risk of life threatening infectious complications of care.

And really this is the fourth of these molecules to kind of graduate from our little pipeline of drug discovery, two of which a topical drug for lymphoma of the skin, an oral substance for the treatment of multiple myeloma will actually come to the bedside for first clinical trial in July of this year.

We're sending his marrow across the country to save the life of a child with leukemia.

It may encourage more people to sign up to be potential live saving bone marrow donors.

But it struck me that I'd never heard of cancer of the heart, or cancer of any skeletal muscle for that matter.

So why should you care? Bone marrow is a very rich source of adult stem cells.

So it enables you to very rapidly aspirate, or suck out, rich bone marrow very quickly through one hole.

Now, one thing that kind of ties the resistance of skeletal muscle to cancer to the cancer as a repair response gone out of control in the body is that skeletal muscle has a factor in it called MyoD.

So the fact that not only did cancer not seem to originate in skeletal muscles, but cancer didn't seem to go to skeletal muscle there seemed to be something here.

And, so, very quickly, Bob can just get one puncture, local anesthesia, and do this harvest as an outpatient.

And ultimately and here's a picture of our bone marrow transplant survivors, who come together for a reunion each year at Stanford.

Throughout this period, the ability to overcome the most common side effect of cancer drugs, myelosuppression (a decrease in blood counts), improved dramatically. It began with the ability to transfuse not only red blood cells into anemic patients, but also platelets, reducing the threat of life threatening bleeding that can accompany cancer therapy.

So these articles were saying, you know, Skeletal metastasis to skeletal muscle is very rare.